Generic Buspar (Buspirone)

Item	Count		Retail	Price	Order
Buspirone 5 mg	30	tablets	$89.70	$74.75
Buspirone 5 mg	60	tablets	$101.70	$84.75
Buspirone 5 mg	90	tablets	$113.70	$94.75

Buspirone Hydrochloride is indicated for the management of anxiety disorders or the short-term relief of the symptoms of anxiety. Buspirone is an agent that is not chemically or pharmacologically related to the benzodiazepines (e.g. Valium, Xanax) barbituates, or other sedative/anti-anxiety drugs.

Buspirone tablets come in 5mg, 10mg, 15mg and 30mg strengths.

HOW DOES Buspirone WORK?

The mechanism of action of Buspirone is not clearly known. Buspirone differs from typical benzodiazepines like Vallium or Xanax anti-anxiety medication in that Buspirone does not exert anti-seizure or muscle relaxant effects. Buspirone also lacks the prominent sedative effect that is associated with benzodiazepines

In vitro studies have shown that Buspirone has a high affinity for serotonin receptors (receptors in the brain that mediate arousal). Buspirone has no significant affinity for benzodiazepine receptors in the brain.

HOW EFFECTIVE IS Buspirone

The excellent efficacy of Buspirone has been demonstrated in controlled clinical trials of outpatients with a diagnosis of Generalized Anxiety Disorder (GAD).

The patients evaluated in these studies had experienced symptoms for periods of 1 month to over 1 year prior to the study, with an average symptom duration of 6 months. Generalized, persistent anxiety (of at least one month continual duration), manifested by symptoms from three of the four following categories :

Motor tension: Shakiness, jitteriness, jumpiness, trembling, tension, muscle aches, fatigability, inability to relax, eyelid twitch, furrowed brow, strained face, fidgeting, restlessness, easy startle.

Autonomic hyperactivity: Sweating, heart pounding or racing, cold, clammy hands, dry mouth, dizziness, lightheadedness, paresthesias (tingling in hands or feet), upset stomach, hot or cold spells, frequent urination, diarrhea, discomfort in the pit of the stomach, lump in the throat, flushing, pallor, high resting pulse and respiration rate.

Apprehensive expectation: Anxiety, worry, fear, rumination, and anticipation of misfortune to self or others.

Vigilance and scanning: Hyper-attentiveness resulting in distractibility, difficulty in concentrating, insomnia, feeling "on edge", irritability, impatience.

The effectiveness of Buspirone in long-term use, that is, for more than 3 to 4 weeks, has not been demonstrated in controlled trials. There is no body of evidence available that systematically addresses the appropriate duration of treatment for GAD. However, in a study of long-term use of Buspirone, 264 patients were treated with Buspirone for 1 year without ill effect. Therefore, the physician who elects to use Buspirone for extended periods should periodically reassess the usefulness of the drug for the individual patient.

Buspirone DOSAGE AND ADMINISTRATION :

The recommended initial dose of Buspirone is 15 mg daily (5 mg 3 times a day). To achieve an optimal therapeutic response, at intervals of 2 to 3 days the Buspirone dosage may be increased 5 mg per day, as needed. The maximum daily dosage of Buspirone should not exceed 60 mg per day. In clinical trials allowing dose titration, divided doses of 20 to 30 mg per day were commonly employed.

Buspirone ADVERSE REACTIONS

The more commonly observed untoward events associated with the use of Buspirone not seen at an equivalent incidence among placebo-treated patients include dizziness, nausea, headache, nervousness, lightheadedness, and excitement.

Other common adverse events associated with Buspirone included: central nervous system disturbances (3.4%), primarily dizziness, insomnia, nervousness, drowsiness, and lightheaded feeling; gastrointestinal disturbances (1.2%), primarily nausea; and miscellaneous disturbances (1.1%), primarily headache and fatigue.

Buspirone interference with cognitive and motor performance: Studies indicate that Buspirone is less sedating than other anti-anxiety medications and that Buspirone does not produce significant functional impairment. However, Buspirone CNS effects in any individual patient may not be predictable.

Therefore, patients should be cautioned about operating an automobile or using complex machinery until they are reasonably certain that Buspirone treatment does not affect them adversely.

While formal studies of the interaction of Buspirone with alcohol indicate that Buspirone does not increase alcohol-induced impairment in motor and mental performance, Buspirone is prudent to avoid concomitant use of alcohol and Buspirone.

Buspirone DRUG ABUSE AND Buspirone DEPENDENCE :

In human and animal studies, Buspirone has shown no potential for abuse or diversion and there is no evidence that it causes tolerance, or either physical or psychological dependence. Human volunteers with a history of recreational drug or alcohol usage were studied in two double-blind clinical investigations. None of the subjects were able to distinguish between Buspirone and placebo. In addition, studies in monkeys, mice, and rats have indicated that Buspirone lacks potential for abuse.

Although there is no direct evidence that Buspirone causes physical dependence or drug-seeking behavior, it is difficult to predict from experiments the extent to which a CNS-active drug will be misused.

BE SURE TO INCLUDE IN YOUR PHYSCIAL EXAMINATION/MEDICAL QUESTIONAIRRE FORM THE FOLLOWING INFORMATION :

Include any medications, prescription or non-prescription, alcohol, or drugs that you are now taking or plan to take during your treatment with Buspirone.

Note if you are pregnant, or if you are planning to become pregnant while you are taking Buspirone.

Note if you are breast-feeding an infant.

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